Preheat your oven to 375 degrees F. Spray a 3 quart 9 x 13 baking dish with cooking spray. Set aside.
Cook macaroni about 1 to 2 minutes shy of al dente in salted water (example - if the box instructs to cook 7 minutes for al dente, cook for 5 to 6 minutes). Drain in a colander and set aside.
Melt the ½ cup of butter in a 6 quart Dutch oven or large pot over medium heat. Slowly add flour, about a tablespoon at a time, while whisking until a smooth paste is formed.
Slowly pour in the heavy cream and milk, whisking frequently until mixture justs starts to boil and is thickened (about 4 minutes).
Add garlic powder, onion powder, salt, and pepper. Stir to combine.
Remove from heat and slowly add cheeses, a large handful at a time, while stirring. Stir until cheese is melted and mixture is combined.
Add cooked and drained macaroni to the cheese mixture. Stir well to coat macaroni evenly. Taste and season with additional seasonings if desired.
Transfer macaroni mixture to the prepared baking dish.
Prepare the topping by combining bread crumbs and melted butter in a small bowl until bread crumbs are evenly coated.
Sprinkle bread crumbs evenly over the macaroni.
Bake (uncovered) for 25 minutes, or until thoroughly heated and bubbly around the edges.
If browning the top is desired, broil on high heat for 1 to 2 minutes, watching carefully to avoid burning the top.
Allow to cool 10 minutes before serving.