Preheat your oven to 375 degrees F. Line a 16x12 rimmed baking sheet with parchment paper. Set aside.
Place bread cubes in a large bowl. Drizzle with olive oil, about a tablespoon at a time, while tossing in-between. Coat bread cubes as evenly as possible.
Sprinkle with Italian seasoning, garlic powder, salt, and pepper. Toss to coat as evenly as possible.
Arrange the bread cubes in a single layer on the prepared baking sheet (without the cubes touching).
Bake for 16 to 18 minutes (or until golden brown and crisp), flipping the bread cubes halfway through baking.
Notes
Once cooled, store the croutons in an airtight container or a resealable zip-top bag at room temperature for 5 to 7 days.
Ovens and baking time may vary - please periodically check the croutons while baking.